Endocrine Abstracts

Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a side effect frequently reported in patients and animal models treated with TPM. Some studies showed that TPM may decrease energy storage, and thus increase energy expenditure and thermogenesis. However, the mechanisms by which TPM reduces body weight are not completely understood. Anorexigenic hormones such as insulin and leptin regulate the activity of d...